Yazar "Ozansoy, Mehmet" için listeleme
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Als2 silencing affects the expression of two NF-κB targeted genes via uxt in adult mouse primary spinal motor neuron culture
Çetin Ozansoy, Muzaffer Beyza; Ozansoy, Mehmet (Logos Medical Publishing, 2018)Aim: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons. Als2 is one of the genes that cause ALS, and its mutations leads to loss of function in alsin protein. The interaction between ... -
Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery
Yamaç, Aylin Hatice; Küçükbuzcu, Sıtkı; Ozansoy, Mehmet; Gök, Özlem; Öz, Kürşat; Ertürk, Mehmet; Yılmaz, Emre; Ersoy, Burak; Zeybek, Rahmi; Göktekin, Ömer; Kılıç, Ülkan (Elsevier Science Inc, 2016)Background: Postoperative atrial fibrillation (POAF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. The expression of the cardioprotective SIRT1 protein with its antioxidant ... -
Alzheimer hastalığında yaşa bağlı hipokampusteki protein profil değişimi ile meydana gelen farklılıklar ve ilişkili yolakların transgenik 5XFAD fare modeli üzerinde incelenmesi
Arzuman, Ayşegül Sümeyye (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Alzheimer Hastalığı en yaygın görülen demaslardan biridir. Fakat, hastalığın mekanizması ve hastalıkla ilgili biyobelirteçler henüz tam olarak açıklığa kavuşmamıştır. Bu çalışmada, 5xFAD transgenik fare modeli ve onların ... -
The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yuluǧ, Burak; Saatçi, Özlem; Işıklar, Aysun; Hanoǧlu, Lütfü; Kılıç, Ülkan; Ozansoy, Mehmet; Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ertuğrul (Bentham Science Publ Ltd, 2020)Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an ... -
Bor içeren bileşiklerin nörodejenerasyona olan olası etkilerinin in vitro aksotomi modelinde araştırılması
Parlatan, Cennet Sena (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Toplumdaki yaşam ömrü ortalamasının artması nörodejeneratif hastalıkların artmasına, bu da araştırmacıların bu konuya olan dikkatlerinin artmasına sebep olmuştur. Sinir sistemi hücrelerinin kabul edilen yargıyla bölünememesi, ... -
Changes in als2 expression leads to different outcomes on the expression of two NF-kB targeted genes in N2a and C2C12 cell lines
Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza (Logos Medical Publishing, 2019)Objective: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting spinal and cortical motor neurons. Motor neuron degeneration leads to progressive muscular atrophy. Als2 (alsin) is one of the causative ... -
Combined therapy with probiotic VSL#3 and Omega-3 fatty acids attenuates colonic injury and inflammation in chronic DNBS-induced colitis in mice
Yoldaş İlktaç, Havvanur; Kızıltan, Gül; Devrim Lanpir, Aslı; Ozansoy, Mehmet; Günal, Mehmet Yalçın; Özmen Togay, Sine; Keskin, İlknur; Özdemir, Ekrem Musa; Kılıç, Ülkan (Polish Academy of Sciences, 2021)Inflammatory bowel disease (IBD) is a progressive chronic inflammatory disease affecting the gastrointestinal tract with a chronic relapsing and remitting disease course. While there are a number of therapeutic strategies ... -
Combined therapy with probiotic VSL#3 and Omega-3 fatty acids attenuates colonic injury and inflammation in chronic DNBS-induced colitis in mice (vol 69, pg 135, 2021)
Yoldaş İlktaç, Havvanur; Kızıltan, Gül; Devrim Lanpir, Aslı; Ozansoy, Mehmet; Günal, Mehmet Yalçın; Özmen Toğay, Sine; Keskin, İlknur; Özdemir, Ekrem Musa; Kılıç, Ülkan (Polish Academy of Sciences, 2022)We published the abovementioned article about probiotic mixture VSL#3 on October 6, 2021. Since the product was named VSL#3 in our purchasing process in early 2016, it is referred to as VSL#3 in our article. In addition, ... -
Corrigenda to “Semiosis as individuation: Integration of multiple orders of magnitude”
Karatay, Vefa; Denizhan, Yağmur; Ozansoy, Mehmet (Springer, 2017)After the online publication of our paper BSemiosis as Individuation: Integration ofMultiple Orders of Magnitude^ (Karatay et al., 2016) in the special issue ofBiosemiotics, we have received a letter from Jean-Hugues ... -
A different view on the pathophysiology of Parkinson’s disease: A descendent neurochemical hypothesis?
Yuluğ, Burak; Ozansoy, Mehmet; Çankaya, Şeyda (Wolters Kluwer, 2019)It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN)neurons. Growing evidence suggests that there is a latent period of PD associated with slight ... -
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
Günal, Mehmet Yalçın; Yuluğ, Burak; Çağlayan, Berrak; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Kılıç, Ertuğrul (Czech Medical Soc, 2019)Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ... -
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Keskin, İlknur; Günal, Mehmet Yalçın; Aytürk, Nilüfer; Kılıç, Ülkan; Ozansoy, Mehmet; Kılıç, Ertuğrul (Medknow Publications & Media Pvt Ltd., 2017)Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ... -
Early stage alterations in CA1 extracellular region proteins indicate dysregulation of IL6 and iron homeostasis in the 5XFAD Alzheimer's disease mouse model
Gürel, Büşra; Cansev, Mehmet; Sevinç, Cansu; Keleştemur, Seda; Öcalan, Büşra; Çakır, Ayşen; Aydın, Sami; Kahveci, Nevzat; Ozansoy, Mehmet; Taşkapılıoğlu, Özlem; Ulus, İsmail Hakkı; Karayel Başar, Merve; Şahin, Betül; Tüzüner, Mete Bora; Baykal, Ahmet Tarık (Ios Press, 2018)In recent years, an increasing number of research papers revealed that the compositional and volumetric alterations in the extracellular matrix are the consequences of aging and may be related to Alzheimer's disease (AD). ... -
The effect of probiotic and omega-3 supplements on total oxidant and total antioxidant levels in experimental colitis
Yoldaş İlktaç, Havvanur; Kızıltan, Gül; Ozansoy, Mehmet; Kılıç, Ülkan; Özmen Toğay, Sine; Keskin, İlknur; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2021)Objective: Treatment of inflammatory bowel disease (IBD) usually involves medical therapy. For this reason, it is recommended to seek alternative treatment methods such as nutritional therapy. The aim of the study is to ... -
The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy
Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ... -
Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza; Yuluğ, Burak; Çankaya, Şeyda; Kılıç, Ertuğrul; Göktekin, Şule; Kılıç, Ülkan (Elsevier Science Ltd., 2020)Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its ...